Of these infections, 19 progressed to severe disease, 4 to critical disease, and 0 to fatal disease.
By December 5, 2021, a total of 2962 breakthrough infections had been recorded among those who received two doses. The median time between the first and second doses was 28 days (interquartile range, 28 to 30). The median date of the first dose was May 27, 2021, and the median date of the second dose was June 27, 2021. Effectiveness was estimated against documented infection (a PCR-positive swab, regardless of the presence of symptoms) and against any severe Covid-19 cases (acute-care hospitalizations), critical Covid-19 cases (intensive care unit hospitalizations), or fatal Covid-19 cases (Covid-19–related deaths).īetween January 1 and December 5, 2021, a total of 893,779 persons received at least one dose of mRNA-1273, and 887,726 completed the two-dose regimen. 3 Case participants (persons with a positive polymerase-chain-reaction test for SARS-CoV-2) and controls (PCR-negative persons) were matched one to one according to sex, 10-year age group, nationality, reason for PCR testing, and calendar week of PCR test. We used a test-negative, case–control study design to estimate vaccine effectiveness, applying the same methods used recently to assess waning effectiveness of the BNT162b2 (Pfizer–BioNTech) vaccine in the same population. 2 We assessed the persistence of real-world vaccine effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and against Covid-19–related hospitalization and death. In early 2021, Qatar launched a mass immunization campaign with the mRNA-1273 (Moderna) 1 vaccine against coronavirus disease 2019 (Covid-19). The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care.
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